If your face is painful or the flaking is too unsightly, the best option is to space out applications. Some people need to apply Retin-A every other night at the beginning, and others need to space it out even more -- every 3 to 4 nights.
After 2 weeks you can increase the frequency of applications until you are able to use it every night. The most important thing is to stick with it and don't give up.
It is possible to be allergic to Retin-A. Allergy symptoms usually are redness, swelling, blistering and/or cracking skin. If you have any questions you should notify your health care provider.