Skin Health Skin Care & Cleansing Products How Does Mederma Cream Work for Scars? By Heather L. Brannon, MD Updated on February 15, 2024 Fact checked by Sheeren Jegtvig Print Table of Contents View All Table of Contents Mederma's Effect What Research Says Alternatives to Mederma If a scar is negatively affecting your level of self-confidence, you may be wondering whether you should try using the over-the-counter topical cream Mederma. This product lists its active ingredient as Allium cepa, or onion extract. This article will discuss Mederma’s use for reducing scars, including its effectiveness, available research, and alternative options. JGI/Jamie Grill / Getty Images Mederma's Effect on Scars If you have a scar on some part of your skin—such as an acne scar, a surgery scar, a burn scar, or a scar from a cut—you might feel embarrassed by it. This may be especially true if it's on an area of skin that tends to be exposed. Perhaps you think it looks unsightly or maybe you're simply tired of explaining what it is when people ask you about it. Mederma scar cream is based on using onion extract. Onion extract has been shown to have anti-inflammatory properties and improve the collagen organization in a rabbit ear model. However, there are no human studies that show onion extract improves the appearance of scars more than petroleum-based ointments. Mederma is safe for those ages 6 months or older. It's not meant for open wounds—it should be used only when a wound is closed and either the scab falls off or the stitches are removed. But is it worth the money? Will Mederma scar cream help your scar become less noticeable? Despite what all the commercials say, the research doesn't support it is better than the usual treatment. Pros Safe for ages 6 months and up Won't make the scar worse Cons Expensive compared with petroleum jelly Promoted by an extensive marketing campaign that's not backed by science Time intensive; manufacturer recommends applying the cream three times a day for eight weeks on new scars and for three to six months on old scars A Mederma cream that contains a sun protective factor (SPF) of 30 for protection against damaging ultraviolet rays is also available. Other products in the Mederma scar care line include: Mederma Quick Dry OilMederma Advanced Scar GelMederma PM Intensive Overnight CreamMederma for Kids Directions for use will vary depending on the type of Mederma product you use. Mederma Advanced Scar Gel and Mederma PM Intensive Overnight Cream should be applied once a day. Mederma Scar Cream Plus SPF 30 should be used up to three times a day before sun exposure. Always check the label for instructions for how each product should be used. Does Mederma Remove Dark Spots? Some dark spots from scars may respond to treatment with Mederma. However, it will not clear up those caused by melanin. These include age spots, freckles, sun spots, and melasma. What Research Says About Mederma According to a small study with 44 participants published in 2012, Mederma gel appeared to improve the overall appearance, softness, and texture of scars if applied via gentle massage three times a day for eight weeks on new scars and three to six months on old scars. While this study was blinded, it compared scars treated with Mederma gel with scars on the same individuals where no treatment was given. Scars form on the skin through a three-stage process and this process can last up to two years after an injury. Many scientists are studying this wound-healing process in an attempt to find something that will make scars less visible. It is widely recognized that moist wounds heal 50% faster than wounds that dry out and develop a scab. Although the previously mentioned study found some benefit, other studies have not replicated those findings when onion extracts were compared with petroleum jelly, including a study published in 2006 and a study published in 2018. Alternatives to Mederma for Scars In addition to Mederma, some other over-the-counter products you can buy in drugstores and online include: ScarAway Clear Silicone Scar SheetsMuraski Beauty Silicone Scar GelKelo-cote Advanced Skincare Formula Scar GelbioCorneum Advanced Scar Treatment + SPF 30 If over-the-counter products aren't effective, your healthcare provider may suggest other treatments or procedures to reduce scarring. Some options may include: Dermal filler injections to reduce scars that are pitted or indentedDermabrasion and chemical peels to smooth the skinLaser therapy to flatten or soften scarsBleaching for discolorationPunch excision to remove acne scars Summary Mederma scar cream contains onion extract, which has been found in animal studies to help improve scarring. However, more research is needed to confirm these benefits for humans. In addition to Mederma, other over-the-counter creams and gels to improve scars are available online and in drugstores. For scarring that doesn't improve with these products, your healthcare provider may suggest other treatments, including dermal filler injections, dermabrasion, and laser therapy. The 9 Best Scar Creams to Fade and Smooth Unwanted Scars, Tested and Reviewed 7 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Saulis AS, Mogford JH, Mustoe TA. Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plastic and Reconstructive Surgery. 2002;110(1):177-183. doi:10.1097/00006534-200207000-00029 Mederma. FAQs. Draelos ZD, Baumann L, Fleischer AB Jr, Plaum S, Avakian EV, Hardas B. A new proprietary onion extract gel improves the appearance of new scars: a randomized, controlled, blinded-investigator study. J Clin Aesthet Dermatol. 2012;5(6):18-24. Karppinen SM, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T. Toward understanding scarless skin wound healing and pathological scarring. F1000Res. 2019;8. doi:10.12688/f1000research.18293.1 Junker JPE, Kamel RA, Caterson EJ, Eriksson E. Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments. Adv Wound Care. 2013;2(7):348-356. doi:10.1089/wound.2012.0412 Owji N, Khademi B, Khalili MR. Effectiveness of topical onion extract gel in the cosmetic appearance of blepharoplasty scar. J Clin Aesthet Dermatol. 2018;11(10):31–35. Johns Hopkins Medicine. Everyday cuts and scrapes: How to prevent scarring. Additional Reading Chung VQ, Kelley L, Marra D, Jiang SB. Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study. Dermatol Surg. 2006;32(2):193-197. doi:10.1111/j.1524-4725.2006.32045.x By Heather L. Brannon, MD Heather L. Brannon, MD, is a family practice physician in Mauldin, South Carolina. She has been in practice for over 20 years. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit